22047-25-2

  • Product NameAcetylpyrazine
  • MFC6H6N2O
  • Molecular Weight122.126
  • Purity99%
  • AppearanceLight yellow to yellow-brownish powder
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Product Details

Quick Details

  • CasNo: 22047-25-2
  • MF: C6H6N2O
  • Appearance: Light yellow to yellow-brownish powder
  • Purity: 99%

Buy Reliable Quality Wholesale Acetylpyrazine 22047-25-2, Offer On Stock with Fast Shipping

  • Molecular Formula:C6H6N2O
  • Molecular Weight:122.126
  • Appearance/Colour:Light yellow to yellow-brownish powder 
  • Vapor Pressure:0.095mmHg at 25°C 
  • Melting Point:75-78 °C 
  • Refractive Index:1.518 
  • Boiling Point:212.9 °C at 760 mmHg 
  • PKA:0.30±0.10(Predicted) 
  • Flash Point:84.4 °C 
  • PSA:42.85000 
  • Density:1.136 g/cm3 
  • LogP:0.67920 
  • IDLH:784 
  • IDLH:2286 
  • IDLH:3126 

Acetylpyrazine(Cas 22047-25-2) Usage

Description

2-acetylpyrazine is white to pale yellow crystalline powder with a nutty, popcorn, bread-crust odor. It is soluble in water and stable under ordinary conditions. It is used to manufacture many polycyclic compounds and used as useful structures in pharmaceuticals and perfumes. It is a component of the folates (vitamin B compounds) and of the isoalloxazine ring nucleus of flavins. Numerous pyrazine derivatives such as pyrazine polycyclic compounds, alkyl-, alicyclic-, and alkylaryl-substituted compounds, derivatives containing oxygenated functional groups and thio-functional groups in the side-chains are used in biological, drug, flavoring and perfumery industry. 2-acetylpyrazine is used as food additive, commonly used in chocolate and baked goods.

Chemical Properties

LIGHT YELLOW TO YELLOW-BROWNISH POWDER

Occurrence

Reported found in guava fruit (Psidium guajava L.), wheaten bread, other types of breads, boiled and cooked beef, grilled/roasted uncured pork, pork liver, cocoa, coffee, black tea, roasted barley, roasted filbert (Corylus avellano), roasted peanut (Arachis hypogea), roasted almond (Prunus amygdalus), scallop, filberts, popcorn and sesame oil.

Uses

Acetylpyrazine has been used in synthesis of:7-heteroaryl-pyrazolo[1,5-a]pyrimidine-3-carboxamidescopper (II) complexes with di-imine ligandsN(4) substituted thiosemicarbazones

Definition

ChEBI: 2-acetylpyrazine is a pyrazine that is substituted by an acetyl group at position 2. It has been identified as one of the volatile flavor constituents in popcorn, bread crust, vinegar, and potato snacks. It has a role as a flavouring agent. It is an aromatic ketone and a member of pyrazines.

Application

Acetylpyrazine has been widely used as an intermediate in the organic synthesis of various heterocyclic derivatives and in coupling reactions, alkylation reactions, and sensitizer ligands because of its good biological and reactive activities. For example, it is a significant reaction intermediate for producing drugs for treating malaria, epilepsy, and Parkinson's disease.

Preparation

synthesis of acetylpyrazine: By the ester condensation of EtO2 C-pyrazine; by dehydrating pyrazynamide with POCI3 and then reacting the resulting 2-cyano-pyrazine with methyl magnesium bromide.

Aroma threshold values

Detection at 62 ppb

Taste threshold values

Taste characteristics at 10 ppm: roasted, nutty, bready, yeasty with popcorn, corn chip nuance

General Description

2-Acetylpyrazine has been identified as one of the volatile flavor constituents in popcorn, wheat and rye bread crust.

Who Evaluation

Evaluation year: 2001

InChI:InChI=1/C6H8N2O/c1-6(9)8-4-2-7-3-5-8/h2-5,7H,1H3

22047-25-2 Relevant articles

Novel thiosemicarbazones derived from formyl- and acyldiazines: Synthesis, effects on cell proliferation, and synergism with antiviral agents

Easmon,Heinisch,Holzer,Rosenwirth

, p. 3288 - 3296 (1992)

The synthesis of a series of novel thios...

Comparison of pyrazines formation in methionine/glucose and corresponding Amadori rearrangement product model

Cui, Heping,Deng, Shibin,Hayat, Khizar,Ho, Chi-Tang,Zhai, Yun,Zhang, Qiang,Zhang, Xiaoming

, (2022/03/07)

The generation of pyrazines in a binary ...

Highly chemoselective deoxygenation of N-heterocyclic: N -oxides under transition metal-free conditions

Kim, Se Hyun,An, Ju Hyeon,Lee, Jun Hee

supporting information, p. 3735 - 3742 (2021/05/04)

Because their site-selective C-H functio...

Iron-catalyzed Minisci acylation of N-heteroarenes with α-keto acids

Wang, Xiu-Zhi,Zeng, Cheng-Chu

supporting information, p. 1425 - 1430 (2019/02/01)

An efficient and mild protocol has been ...

Method for synthesizing 2-acetyl pyrazine

-

Paragraph 0022-0029, (2019/06/27)

The invention relates to the field of ch...

22047-25-2 Process route

L-serin
56-45-1,83245-15-2

L-serin

L-lysine
56-87-1,3506-25-0

L-lysine

D-glucose
50-99-7

D-glucose

1,4-pyrazine
290-37-9

1,4-pyrazine

2-Methylpyrazine
109-08-0

2-Methylpyrazine

2,5-dimethyl-pyrazine
123-32-0

2,5-dimethyl-pyrazine

2,3-dimethylpyrazine
5910-89-4

2,3-dimethylpyrazine

acetylpyrazine
22047-25-2

acetylpyrazine

2-ethyl-3,6-dimethylpyrazine
13360-65-1

2-ethyl-3,6-dimethylpyrazine

2,6-dimethylpyrazine
108-50-9

2,6-dimethylpyrazine

2,3,5-trimethylpyrazine
14667-55-1

2,3,5-trimethylpyrazine

2-ethyl-6-methylpyrazine
13925-03-6

2-ethyl-6-methylpyrazine

2-ethyl-5-methypyrazine
13360-64-0

2-ethyl-5-methypyrazine

Conditions
Conditions Yield
In water; at 130 ℃; for 2h; pH=8;
 
L-lysine
56-87-1,3506-25-0

L-lysine

D-glucose
50-99-7

D-glucose

1,4-pyrazine
290-37-9

1,4-pyrazine

2-Methylpyrazine
109-08-0

2-Methylpyrazine

2,5-dimethyl-pyrazine
123-32-0

2,5-dimethyl-pyrazine

2,3-dimethylpyrazine
5910-89-4

2,3-dimethylpyrazine

acetylpyrazine
22047-25-2

acetylpyrazine

2-ethyl-3,6-dimethylpyrazine
13360-65-1

2-ethyl-3,6-dimethylpyrazine

2,6-dimethylpyrazine
108-50-9

2,6-dimethylpyrazine

2,3,5-trimethylpyrazine
14667-55-1

2,3,5-trimethylpyrazine

2-ethyl-3,5-dimethylpyrazine
13925-07-0

2-ethyl-3,5-dimethylpyrazine

2-ethyl-5-methypyrazine
13360-64-0

2-ethyl-5-methypyrazine

Conditions
Conditions Yield
In water; at 130 ℃; for 2h; pH=8;
 

22047-25-2 Upstream products

  • 19847-12-2
    19847-12-2

    2-pyrazine carbonitrile

  • 75-16-1
    75-16-1

    methylmagnesium bromide

  • 290-37-9
    290-37-9

    1,4-pyrazine

  • 75-07-0
    75-07-0

    acetaldehyde

22047-25-2 Downstream products

  • 74476-22-5
    74476-22-5

    (E)-3-(3-Hydroxy-4-methoxy-phenyl)-1-pyrazin-2-yl-propenone

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    74476-18-9

    (E)-3-(3-Ethoxy-4-hydroxy-phenyl)-1-pyrazin-2-yl-propenone

  • 74476-16-7
    74476-16-7

    (E)-3-(3-Ethoxy-2-hydroxy-phenyl)-1-pyrazin-2-yl-propenone

  • 74475-98-2
    74475-98-2

    (E)-3-(4-Chloro-phenyl)-1-pyrazin-2-yl-propenone

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